Kalp ve damar hastal\u0131klar\u0131, d\u00fcnya genelinde en \u00f6nemli \u00f6l\u00fcm nedenleri aras\u0131nda yer al\u0131yor. Kalp ve beyin damarlar\u0131n\u0131n daralmas\u0131 ya da t\u0131kanmas\u0131; kalp krizi, inme ve fel\u00e7 gibi ciddi sonu\u00e7lara yol a\u00e7abiliyor.<\/p>\n
Damar t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131n temelinde damar duvar\u0131n\u0131n zaman i\u00e7inde bozulmas\u0131, kolesterol birikimi ve damar sertli\u011fi gibi mekanizmalar\u0131n bulundu\u011fu biliniyor. Ya\u015f, sigara kullan\u0131m\u0131, diyabet ve y\u00fcksek tansiyon gibi fakt\u00f6rler de bu s\u00fcreci h\u0131zland\u0131rabiliyor.<\/p>\n
Ancak yeni bir bilimsel \u00e7al\u0131\u015fma, aterom plaklar\u0131n\u0131n olu\u015fumunda mikroorganizmalar\u0131n da rol oynayabilece\u011fi ihtimalini g\u00fcndeme ta\u015f\u0131d\u0131.<\/p>\n
T\u0131p Fak\u00fcltesi T\u0131bbi Mikrobiyoloji Anabilim Dal\u0131 Ba\u015fkan\u0131 Prof. Dr. Tan\u0131l Kocag\u00f6z ve ekibi, damar t\u0131kan\u0131kl\u0131\u011f\u0131 nedeniyle ameliyat veya giri\u015fimsel i\u015flemler s\u0131ras\u0131nda \u00e7\u0131kar\u0131lan aterom plaklar\u0131n\u0131 inceledi.<\/p>\n
Ara\u015ft\u0131rma kapsam\u0131nda 20 \u00f6rnek \u00fczerinde yap\u0131lan incelemede, 8 \u00f6rnekte Toxoplasma gondii<\/em> parazitinin DNA\u2019s\u0131na rastland\u0131.<\/strong><\/p>\n Prof. Dr. Kocag\u00f6z, konuya ili\u015fkin \u015fu ifadeleri kulland\u0131:<\/p>\n \u201cDamar t\u0131kan\u0131kl\u0131\u011f\u0131 y\u0131llard\u0131r b\u00fcy\u00fck \u00f6l\u00e7\u00fcde damar sertli\u011fi ve kolesterol birikimi \u00fczerinden a\u00e7\u0131klan\u0131yor. Ancak biz \u015fu soruyu sorduk: Acaba damarlar\u0131 t\u0131kayan aterom plaklar\u0131n\u0131n olu\u015fumunda mikroorganizmalar\u0131n da bir rol\u00fc olabilir mi?\u201d<\/p>\n Kocag\u00f6z, daha \u00f6nce baz\u0131 mikroorganizmalar\u0131n damar hastal\u0131klar\u0131yla ili\u015fkili olabilece\u011finin \u00f6ne s\u00fcr\u00fcld\u00fc\u011f\u00fcn\u00fc, ancak bug\u00fcne kadar damar t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131n do\u011frudan nedeni oldu\u011funa ili\u015fkin kesin bir kan\u0131t elde edilemedi\u011fini belirtti.<\/p>\n Ara\u015ft\u0131rma s\u00fcrecini anlatan Kocag\u00f6z, \u015funlar\u0131 s\u00f6yledi:<\/p>\n \u201cDamar t\u0131kan\u0131kl\u0131\u011f\u0131 nedeniyle ameliyat veya giri\u015fimsel i\u015flemler s\u0131ras\u0131nda \u00e7\u0131kar\u0131lan aterom plaklar\u0131n\u0131 inceledik. Bu dokular\u0131n t\u00fcm DNA\u2019s\u0131n\u0131 analiz ederek \u00f6zellikle mikrobiyal DNA \u00fczerinde yo\u011funla\u015ft\u0131k. Ve sonu\u00e7 olarak b\u00fcy\u00fck bir s\u00fcrprizle kar\u015f\u0131la\u015ft\u0131k. 20 \u00f6rne\u011fin 8\u2019inde, yani neredeyse yar\u0131s\u0131nda Toxoplasma gondii<\/em> parazitinin DNA\u2019s\u0131na rastlad\u0131k. \u0130nceledi\u011fimiz \u00f6rneklerde ba\u015fka bir mikroorganizmaya ait DNA\u2019ya rastlamad\u0131k.\u201d<\/p>\n Ancak ara\u015ft\u0131rmac\u0131lar, yaln\u0131zca parazit DNA\u2019s\u0131n\u0131n bulunmas\u0131n\u0131n damar t\u0131kan\u0131kl\u0131\u011f\u0131na neden oldu\u011fu anlam\u0131na gelmedi\u011finin alt\u0131n\u0131 \u00e7iziyor.<\/p>\n Ara\u015ft\u0131rman\u0131n yeni a\u015famas\u0131nda, aterom plaklar\u0131ndaki parazitin canl\u0131 olup olmad\u0131\u011f\u0131 ve \u00e7o\u011fal\u0131p \u00e7o\u011falmad\u0131\u011f\u0131 incelenecek.<\/p>\n Prof. Dr. Kocag\u00f6z, \u015fu de\u011ferlendirmeyi yapt\u0131:<\/p>\n \u201cParazitin DNA\u2019s\u0131n\u0131 bulmu\u015f olmam\u0131z, tek ba\u015f\u0131na bu parazitin damar t\u0131kan\u0131kl\u0131\u011f\u0131na neden oldu\u011funu kan\u0131tlam\u0131yor. \u015eimdi as\u0131l soruya yan\u0131t ar\u0131yoruz: Bu parazit ger\u00e7ekten damarda canl\u0131 olarak bulunuyor ve \u00e7o\u011fal\u0131yor mu? Bunu kan\u0131tlarsak gelecekte basit bir antibiyotik tedavisiyle damar t\u0131kan\u0131kl\u0131klar\u0131 engellenebilir, kalp krizi, fel\u00e7 gibi s\u0131k\u0131nt\u0131lar da \u00f6nlenebilir.\u201d<\/p>\n Toxoplasma gondii<\/em>, toplumda yayg\u0131n olarak g\u00f6r\u00fclen bir parazit olarak biliniyor.<\/p>\n \u0130nsanlara \u00e7o\u011funlukla yeterince pi\u015firilmemi\u015f et, kontamine su veya uygun \u015fekilde temizlenmemi\u015f g\u0131dalar yoluyla bula\u015fabiliyor. Enfeksiyon sonras\u0131nda v\u00fccudun \u00e7e\u015fitli dokular\u0131nda uzun s\u00fcre kalabiliyor.<\/p>\n Ara\u015ft\u0131rmac\u0131lar ise parazitin aterom pla\u011f\u0131nda bulunmas\u0131n\u0131n ne anlama geldi\u011fini ortaya koymaya \u00e7al\u0131\u015f\u0131yor.<\/p>\n T\u00dcB\u0130TAK taraf\u0131ndan desteklenmesi kabul edilen proje kapsam\u0131nda, aterom plaklar\u0131nda bulunan parazitin canl\u0131l\u0131\u011f\u0131 ve \u00e7o\u011falma kapasitesi incelenecek.<\/p>\n Prof. Dr. Kocag\u00f6z, \u015fu ifadeleri kulland\u0131:<\/p>\n \u201cE\u011fer parazitin, aterom pla\u011f\u0131nda canl\u0131 oldu\u011funu g\u00f6sterebilir ve burada \u00e7o\u011fald\u0131\u011f\u0131n\u0131 ortaya koyabilirsek, bunun yaln\u0131zca ge\u00e7mi\u015ften kalm\u0131\u015f bir DNA par\u00e7as\u0131 olmad\u0131\u011f\u0131n\u0131, aktif bir enfeksiyon etkeni olabilece\u011fini daha g\u00fc\u00e7l\u00fc bi\u00e7imde ortaya koyabiliriz.\u201d<\/p>\n Damar t\u0131kan\u0131kl\u0131\u011f\u0131nda yaln\u0131zca mevcut daralma de\u011fil, pla\u011f\u0131n zaman i\u00e7inde b\u00fcy\u00fcmesi de b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yor.<\/p>\n Kocag\u00f6z, olas\u0131 bir tedavinin pla\u011f\u0131 tamamen ortadan kald\u0131rmasa bile b\u00fcy\u00fcmesini durdurmas\u0131n\u0131n \u00f6nemli bir klinik fayda sa\u011flayabilece\u011fini belirtti.<\/p>\n \u201cDamar\u0131n y\u00fczde 50 oran\u0131nda t\u0131kal\u0131 oldu\u011funu d\u00fc\u015f\u00fcnelim. E\u011fer bir tedaviyle bu pla\u011f\u0131n b\u00fcy\u00fcmesini durdurabiliyorsak, bu bile \u00f6nemli bir kazan\u0131m olabilir. \u00c7\u00fcnk\u00fc pla\u011f\u0131n ilerlemesini engellemek, damar\u0131n daha ileri d\u00fczeyde t\u0131kanmas\u0131n\u0131 ve buna ba\u011fl\u0131 kalp krizi veya inme riskinin artmas\u0131n\u0131 \u00f6nlemeye katk\u0131 sa\u011flayabilir.\u201d<\/p>\n Ara\u015ft\u0131rmada Toxoplasma gondii<\/em> parazitinin damar pla\u011f\u0131nda canl\u0131l\u0131\u011f\u0131n\u0131 s\u00fcrd\u00fcrd\u00fc\u011f\u00fc ve pla\u011f\u0131n b\u00fcy\u00fcmesine katk\u0131 sa\u011flad\u0131\u011f\u0131 bilimsel olarak kan\u0131tlan\u0131rsa, gelecekte kalp ve damar hastal\u0131klar\u0131n\u0131n tedavisinde yeni bir yakla\u015f\u0131m g\u00fcndeme gelebilir.<\/p>\n Bu durumda mevcut pla\u011f\u0131 hedeflemek yerine enfeksiyon etkenini hedefleyen antibiyotik tedavileri<\/strong> de\u011ferlendirilebilir.<\/p>\n Ara\u015ft\u0131rmac\u0131lar, benzer mekanizmalar\u0131n yaln\u0131zca kalp damarlar\u0131nda de\u011fil, beyne kan ta\u015f\u0131yan \u015fah damar\u0131 gibi damarlarda da ara\u015ft\u0131r\u0131labilece\u011fini belirtiyor.<\/p>\n Ara\u015ft\u0131rman\u0131n yakla\u015f\u0131k 1-1,5 y\u0131l i\u00e7inde<\/strong> sonu\u00e7lanmas\u0131 bekleniyor.<\/p>\n Prof. Dr. Tan\u0131l Kocag\u00f6z, \u00e7al\u0131\u015fman\u0131n hen\u00fcz ara\u015ft\u0131rma a\u015famas\u0131nda oldu\u011funa dikkat \u00e7ekerek \u015fu ifadeleri kulland\u0131:<\/p>\n \u201c\u015eu anda elimizde umut verici bir bulgu var; ancak bu bulgunun tedaviye d\u00f6n\u00fc\u015febilmesi i\u00e7in \u00f6n\u00fcm\u00fczde kat edilmesi gereken \u00f6nemli bir bilimsel yol bulunuyor.\u201d<\/p>\n \u00c7al\u0131\u015fma hen\u00fcz klinik uygulamaya d\u00f6n\u00fc\u015fm\u00fc\u015f bir tedavi sunmuyor ancak damar t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131n nedenlerinin anla\u015f\u0131lmas\u0131 ve gelecekte yeni tedavi y\u00f6ntemlerinin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan dikkat \u00e7ekici bir ara\u015ft\u0131rma olarak \u00f6ne \u00e7\u0131k\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":" Kalp ve damar hastal\u0131klar\u0131n\u0131n en \u00f6nemli sonu\u00e7lar\u0131ndan biri olan damar t\u0131kan\u0131kl\u0131\u011f\u0131na ili\u015fkin y\u00fcr\u00fct\u00fclen yeni bir ara\u015ft\u0131rma, aterom plaklar\u0131nda Toxoplasma gondii parazitinin DNA\u2019s\u0131na rastland\u0131\u011f\u0131n\u0131 ortaya koydu. Ara\u015ft\u0131rmac\u0131lar, bu parazitin damar t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131n olu\u015fumunda ve ilerlemesinde aktif rol oynay\u0131p oynamad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131r\u0131yor. E\u011fer bu ili\u015fki kan\u0131tlan\u0131rsa, gelecekte baz\u0131 damar t\u0131kan\u0131kl\u0131klar\u0131nda enfeksiyonu hedefleyen antibiyotik tedavileri g\u00fcndeme gelebilir.<\/p>\n","protected":false},"author":14,"featured_media":50591,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[15845,13716,6550],"class_list":["post-50590","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-damar-tikanikligi","tag-inme","tag-kalp-krizi"],"yoast_head":"\n20 \u00f6rne\u011fin 8\u2019inde rastland\u0131<\/h3>\n
\u015eimdi kritik soru ara\u015ft\u0131r\u0131l\u0131yor: Parazit canl\u0131 m\u0131?<\/h3>\n
Toxoplasma toplumda yayg\u0131n g\u00f6r\u00fcl\u00fcyor<\/h3>\n
T\u00dcB\u0130TAK destekli yeni a\u015fama<\/h3>\n
Pla\u011f\u0131n b\u00fcy\u00fcmesini durdurmak bile \u00f6nemli olabilir<\/h3>\n
Antibiyotik tedavisi g\u00fcndeme gelebilir<\/h3>\n
\u00c7al\u0131\u015fman\u0131n 1-1,5 y\u0131l i\u00e7inde sonu\u00e7lanmas\u0131 bekleniyor<\/h3>\n