\u00c7ocukluk \u00e7a\u011f\u0131nda g\u00f6r\u00fclen kanserlerin yakla\u015f\u0131k y\u00fczde 30 ila 35\u2019ini l\u00f6semiler olu\u015ftururken, her y\u0131l yakla\u015f\u0131k her 100 bin \u00e7ocuktan 3 ila 4\u2019\u00fcne l\u00f6semi tan\u0131s\u0131 konuluyor. En s\u0131k g\u00f6r\u00fclen t\u00fcr olan akut lenfoblastik l\u00f6semi ise \u00f6zellikle 2 ile 5 ya\u015f aras\u0131ndaki \u00e7ocuklarda daha s\u0131k ortaya \u00e7\u0131k\u0131yor. Memorial Bah\u00e7elievler Hastanesi \u00c7ocuk Hematoloji ve Onkoloji B\u00f6l\u00fcm\u00fc\u2019nden Prof. Dr. Bar\u0131\u015f Malbora, erken tan\u0131, geli\u015fmi\u015f laboratuvar y\u00f6ntemleri, ki\u015fiselle\u015ftirilmi\u015f tedaviler ve destekleyici bak\u0131m sayesinde \u00e7ocukluk \u00e7a\u011f\u0131 l\u00f6semilerinde iyile\u015fme oranlar\u0131n\u0131n y\u00fczde 90\u2019lar\u0131n \u00fczerine \u00e7\u0131kt\u0131\u011f\u0131n\u0131 s\u00f6yledi.<\/p>\n
L\u00f6seminin, kemik ili\u011finde kan h\u00fccrelerini \u00fcreten h\u00fccrelerin kontrols\u00fcz \u00e7o\u011falmas\u0131 sonucu geli\u015fen bir kanser t\u00fcr\u00fc oldu\u011funu belirten Prof. Dr. Malbora, bu durumun sa\u011fl\u0131kl\u0131 alyuvar \u00fcretimini azaltt\u0131\u011f\u0131n\u0131, trombosit seviyelerini d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fcn\u00fc ve normal akyuvarlar\u0131n kontrols\u00fcz bi\u00e7imde \u00e7o\u011falmas\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 ifade etti. Bu nedenle \u00e7ocuklarda kans\u0131zl\u0131k, s\u0131k enfeksiyon, morarma ve kanama gibi tablolar\u0131n ortaya \u00e7\u0131kabildi\u011fini kaydeden Malbora, \u00e7ocukluk \u00e7a\u011f\u0131 l\u00f6semilerinin b\u00fcy\u00fck b\u00f6l\u00fcm\u00fcn\u00fcn akut ve h\u0131zl\u0131 ilerleyen t\u00fcrlerden olu\u015ftu\u011funu anlatt\u0131.<\/p>\n
Prof. Dr. Malbora, \u00e7ocukluk \u00e7a\u011f\u0131 l\u00f6semilerinin genel olarak \u00fc\u00e7 ana grupta de\u011ferlendirildi\u011fini, bunlar aras\u0131nda en s\u0131k rastlanan tipin \u00e7ocukluk \u00e7a\u011f\u0131 l\u00f6semilerinin yakla\u015f\u0131k y\u00fczde 75 ila 80\u2019ini olu\u015fturan akut lenfoblastik l\u00f6semi oldu\u011funu belirtti. \u0130kinci s\u0131rada akut miyeloid l\u00f6seminin geldi\u011fini, bunun d\u0131\u015f\u0131nda daha seyrek g\u00f6r\u00fclen kronik l\u00f6semi t\u00fcrlerinin de bulundu\u011funu s\u00f6yledi. L\u00f6semi tipinin do\u011fru belirlenmesinin tedavinin planlanmas\u0131 ve ba\u015far\u0131 \u015fans\u0131n\u0131n art\u0131r\u0131lmas\u0131 a\u00e7\u0131s\u0131ndan b\u00fcy\u00fck \u00f6nem ta\u015f\u0131d\u0131\u011f\u0131na dikkat \u00e7ekti.<\/p>\n
Hastal\u0131\u011f\u0131n belirtilerine ili\u015fkin de bilgi veren Malbora, kemik ve eklem a\u011fr\u0131lar\u0131, lenf bezlerinde b\u00fcy\u00fcme, kar\u0131nda \u015fi\u015flik ve dolgunluk hissi, i\u015ftahs\u0131zl\u0131k, nedensiz kilo kayb\u0131, ciltte d\u00f6k\u00fcnt\u00fcler, di\u015f etlerinde \u015fi\u015fme ve kanama, ba\u015f a\u011fr\u0131s\u0131, kusma ve g\u00f6rme bozukluklar\u0131n\u0131n l\u00f6semi belirtisi olabilece\u011fini ifade etti. Bu belirtilerin ba\u015fka hastal\u0131klarda da g\u00f6r\u00fclebilece\u011fini ancak uzun s\u00fcrmesi halinde mutlaka \u00e7ocuk doktoruna ba\u015fvurulmas\u0131 gerekti\u011fini vurgulad\u0131.<\/p>\n
Tan\u0131 s\u00fcrecinde kan say\u0131m\u0131 ve periferik yayma ile ilk de\u011ferlendirmenin yap\u0131ld\u0131\u011f\u0131n\u0131 aktaran Malbora, kesin tan\u0131 ve risk s\u0131n\u0131flamas\u0131 i\u00e7in kemik ili\u011fi incelemesi, h\u00fccrelerin ayr\u0131nt\u0131l\u0131 analizi, genetik incelemeler, belden s\u0131v\u0131 alma i\u015flemi, kan biyokimya testleri ve gerekli durumlarda ultrason, tomografi ya da MR gibi g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemlerinin kullan\u0131ld\u0131\u011f\u0131n\u0131 belirtti. Bu testlerin, hastal\u0131\u011f\u0131n tipini belirleyerek en uygun tedavi plan\u0131n\u0131n olu\u015fturulmas\u0131na katk\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 ifade etti.<\/p>\n
\u00c7ocukluk \u00e7a\u011f\u0131 l\u00f6semilerinde tedavinin hastal\u0131\u011f\u0131n tipine ve risk grubuna g\u00f6re \u015fekillenen multidisipliner bir s\u00fcre\u00e7 oldu\u011funa i\u015faret eden Prof. Dr. Malbora, tedavide kemoterapi, radyoterapi, hedefe y\u00f6nelik ila\u00e7lar, imm\u00fcnoterapi, gerekti\u011finde k\u00f6k h\u00fccre nakli ve destek tedavilerinin birlikte kullan\u0131labildi\u011fini s\u00f6yledi. \u00d6zellikle akut lenfoblastik l\u00f6semide g\u00fcncel tedavi protokolleriyle ba\u015far\u0131 oranlar\u0131n\u0131n olduk\u00e7a y\u00fcksek oldu\u011funu belirten Malbora, erken tan\u0131 alan \u00e7ocuklar\u0131n \u00f6nemli bir k\u0131sm\u0131n\u0131n tamamen iyile\u015ferek sa\u011fl\u0131kl\u0131 ya\u015famlar\u0131na d\u00f6nebildi\u011fini kaydetti.<\/p>\n
Prof. Dr. Malbora, erken te\u015fhisin tedavi \u015fans\u0131n\u0131 y\u00fckseltti\u011fini, tedavinin yo\u011funlu\u011fu ile yan etkilerini azaltt\u0131\u011f\u0131n\u0131 ve k\u00f6k h\u00fccre nakli ihtiyac\u0131n\u0131 d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fcn\u00fc s\u00f6yledi. Son y\u0131llarda k\u00f6k h\u00fccre nakli alan\u0131nda da \u00f6nemli geli\u015fmeler ya\u015fand\u0131\u011f\u0131n\u0131 belirten Malbora, ge\u00e7mi\u015fte tam uyumlu verici bulunamamas\u0131n\u0131n \u00f6nemli bir sorun oldu\u011funu ancak bug\u00fcn anne, baba veya karde\u015f gibi aile bireylerinden al\u0131nan yar\u0131 uyumlu nakillerin de g\u00fcvenli ve ba\u015far\u0131l\u0131 \u015fekilde uygulanabildi\u011fini ifade etti. Kordon kan\u0131ndan elde edilen k\u00f6k h\u00fccrelerin \u00f6zel y\u00f6ntemlerle \u00e7o\u011falt\u0131lmas\u0131n\u0131n da daha fazla \u00e7ocuk i\u00e7in umut olu\u015fturdu\u011funu s\u00f6zlerine ekledi.<\/p>\n","protected":false},"excerpt":{"rendered":"
Uzmanlar, \u00e7ocukluk \u00e7a\u011f\u0131 kanserlerinin \u00f6nemli b\u00f6l\u00fcm\u00fcn\u00fc olu\u015fturan l\u00f6semide erken tan\u0131 ve ki\u015fiye \u00f6zel tedaviyle iyile\u015fme oranlar\u0131n\u0131n y\u00fczde 90\u2019\u0131n \u00fczerine \u00e7\u0131kt\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n","protected":false},"author":6,"featured_media":17721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[6079,6463],"class_list":["post-17720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-cocuk-sagligi","tag-losemi"],"yoast_head":"\n